In a 12-month, placebo-controlled study in paediatric patients 2 to 5 years of age with mild asthma and episodic exacerbations, montelukast 4 mg once daily significantly (p≤ ) reduced the yearly rate of asthma exacerbation episodes (EE) compared with placebo ( EE vs. EE, respectively), [EE defined as ≥ 3 consecutive days with daytime symptoms requiring β-agonist use, or corticosteroids (oral or inhaled), or hospitalisation for asthma]. The percentage reduction in yearly EE rate was %, with a 95% CI of , .
Significant reduction of exercise-induced bronchoconstriction (EIB) was demonstrated in a 12-week study in adults (maximal fall in FEV 1 % for montelukast vs % for placebo; time to recovery to within 5% of baseline FEV 1 min vs min). This effect was consistent throughout the 12-week study period. Reduction in EIB was also demonstrated in a short term study in paediatric patients 6 to 14 years of age (maximal fall in FEV 1 % vs %; time to recovery to within 5% of baseline FEV 1 min vs min). The effect in both studies was demonstrated at the end of the once-daily dosing interval.
My son was on Singulair and Zyrtec off and on from the time he was about 1-1/2 because of allergies and ear infections. Although we stopped Singulair at about the age of 2, we continued with Zyrtec. He is 3yrs,4mos old and for the last year and a half we have dealt with aggression, temper tantrums that are short lived, but extremely explosive, and lots of hitting, etc. We really just thought his personality was very different from our first son. We were dealing with his behavior with consequences, but it was breaking our hearts. He just seemed so angry! Two weeks ago, I began doing some research and found, as you did, so many parents talking about these types of behaviors associated with the use of Zyrtec.....We stopped giving it to him immediately. We have seen a dramatic change in his behavior. He is still our strong willed and stubborn little thing, but he has appropriate self control for a 3yr. old. In the last two weeks he has had only two or three timeouts, where as before, we were having many timeouts every day. I can reason with him and explain to him now without having an immediate escalation in his behavior. My husband and I feel so terrible because we feel like that medication made it impossible for him to meet our expectations for behavior. We were disciplining him repeatedly for things that he could not control. I pray that these side effects become more widely publicized so that other families do not experience what we have in the last 18 months. Good luck to you and your family. I feel sure you will notice a change in your little boy's demeanor!