Intranasal corticosteroids for allergic rhinitis how do different agents compare

There is about 20 mL capacity in the adult human nasal cavity . [11] The major part of the approximately 150 cm 2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm 2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly. [12] [13]

A pivotal concept in the usage of nootropics is to pass the brain barrier. Nasal administration allowed me to perfect opportunity to do so. The cavity of the nose is covered in thin mucosa which are well vascularised making it an ideal entry point for nootropics. [3] The nose enables certain drugs and other molecules to bypass the blood brain barrier via diffusion through the olfactory epithelium and the perineural sheath or via retrograde axonal transport along olfactory and trigeminal nerves. Certain nootropic agents like Adrafinil shouldn’t be absorbed via the nose due to the active ingredients that need to be processed by the liver. [4]
After browsing many web pages, online forums and blogs, I found it was easy to procure pre-made nasal sprays capable of dispensing nootropics . However, I’d decided to create my own mixture purely out of curiosity more so than economic benefit. I purchased a 10 ml nasal spray bottle that would be capable of delivering a 4 mg spray of Noopept .

Intranasal corticosteroids for allergic rhinitis how do different agents compare

intranasal corticosteroids for allergic rhinitis how do different agents compare

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