Considering the developmental cost and the success rates associated with the new chemical entities, there is limited potential for developing novel synthetic retinoids. At the same time, retinoid-like activity as shown by PADMA 28 opens a new era in the identification of natural products for anti-aging treatment. As natural products have the well known benefit of good acceptability we expect stimulation in this area of research. Combination therapy has been well established for cutaneous disorders like acne and psoriasis. As relatively less developmental efforts are required for commercializing new combinations, there is scope for developing retinoid based combination therapies for improved treatment of aging. Finally, in our opinion, there is great scope for development of various drug delivery systems (especially nanoparticulate systems) to optimize the aging treatment with topical retinoids. We believe that among various nanoparticulate carriers, SLNs would have the greatest potential in optimizing the retinoid therapy as apart from their advantage as a carrier they are also known to have a UV-blocking effect, which may help in reducing photosensitization induced by retinoids. Interestingly, in one study, a SLN-based anti-aging product was more effective in reducing the depth of wrinkles (%) as compared with the same product based on conventional vehicle (%) indicating that SLNs themselves may have some effect on improving wrinkling ( Muller et al 2002 ). We believe that future efforts in SLNs should be focused on proving its potential to counteract photosensitivity and to identify the potential of SLNs (blank or in combination with retinoids) in improving the elasticity and wrinkling of intrinsically/photo aged skin. Finally, complementary efforts from clinicians are required to validate the potential of drug delivery strategies in optimizing treatment of aging with topical retinoids.