Glucocorticoids together with mineralocorticoids are used in replacement therapy in acute or chronic adrenal insufficiency ( Addison disease ). Glucocorticoids, including a range of synthetic analogs (., prednisolone, triamcinolone, and dexamethasone), are also used as anti-inflammatory and immunosuppressant agents. As anti-inflammatory agents, they are used in the treatment of bronchial asthma . Glucocorticoids indirectly inhibit the activity of phospholipase A 2 , an enzyme that plays an essential role in the synthesis of prostaglandins and leukotrienes; its inhibition by lipocortin-1 underlies part of the anti-inflammatory effects of glucocorticoids. Glucocorticoids also reduce the synthesis of some proteins that directly mediate the inflammatory response.
Many hormones and their structural and functional analogs are used as medication . The most commonly prescribed hormones are estrogens and progestogens (as methods of hormonal contraception and as HRT ),  thyroxine (as levothyroxine , for hypothyroidism ) and steroids (for autoimmune diseases and several respiratory disorders ). Insulin is used by many diabetics . Local preparations for use in otolaryngology often contain pharmacologic equivalents of adrenaline , while steroid and vitamin D creams are used extensively in dermatological practice.