Hematological effects of steroids

The most frequent adverse reactions to Efudex occur locally and are often related to an extension of the pharmacological activity of the drug. These include burning, crusting, allergic contact dermatitis , pruritus , scarring, rash, soreness, and ulceration . Ulcerations, other local reactions, cases of miscarriage and a birth defect ( ventricular septal defect ) have been reported when Efudex was applied to mucous membrane areas. Leukocytosis is the most frequent hematological side effect. Although a causal relationship is remote, other adverse reactions which have been reported infrequently are:

Other autoimmune diseases that have been treated with rituximab include autoimmune hemolytic anemia , pure red cell aplasia , thrombotic thrombocytopenic purpura (TTP), [17] idiopathic thrombocytopenic purpura (ITP), [18] [19] Evans syndrome , [20] vasculitis (., granulomatosis with polyangiitis ), bullous skin disorders (for example pemphigus , pemphigoid —with very encouraging results of approximately 85% rapid recovery in pemphigus, according to a 2006 study), [21] type 1 diabetes mellitus , Sjogren's syndrome , anti-NMDA receptor encephalitis and Devic's disease , [22] Graves' ophthalmopathy , [23] autoimmune pancreatitis , [24] Opsoclonus myoclonus syndrome (OMS), [25] and IgG4-related disease . [26] There is some evidence that it is ineffective in treating IgA-mediated autoimmune diseases. [27]

The most common clinical presentation is abdominal pain [ 45 ], nausea, vomiting, and malaise, which may resemble viral hepatitis, particularly if the serums AST and LDH are markedly elevated [ 46 ]. Hypertension and proteinuria are present in approximately 85 percent of the cases. Differential diagnosis includes acute fatty liver of pregnancy (AFLP). Prolongation of the prothrombin time activated partial thromboplastin time (aPTT), low glucose and elevated creatinine concentrations are more common in women with AFLP than those with HELLP.

Doxorubicin is not a vesicant but should be considered an irritant and precautions should be taken to avoid extravasation. With intravenous administration of liposomal doxorubicin, extravasation may occur with or without an accompanying stinging or burning sensation even if blood returns well on aspiration of the infusion needle. If any signs or symptoms of extravasation have occurred, the infusion should be immediately terminated and restarted in another vein. The application of ice over the side of extravasation for approximately 30 minutes may be helpful in alleviating the local reaction.

Hematological effects of steroids

hematological effects of steroids

Doxorubicin is not a vesicant but should be considered an irritant and precautions should be taken to avoid extravasation. With intravenous administration of liposomal doxorubicin, extravasation may occur with or without an accompanying stinging or burning sensation even if blood returns well on aspiration of the infusion needle. If any signs or symptoms of extravasation have occurred, the infusion should be immediately terminated and restarted in another vein. The application of ice over the side of extravasation for approximately 30 minutes may be helpful in alleviating the local reaction.

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