Corticosteroids like prednisone, have many drug interactions; examples include: Studies have demonstrated that it can also be carefully combined with methotrexate in patients with no preexisting liver disease, as long as the liver function tests are carefully monitored. Other toxicities that are common include mild diarrhea, GI upset and alopecia and hair thinning sometimes of sufficient severity to cause cessation of the drug. Ruffing has been a member of the Arthritis Center since , currently serving as the Nurse Manager. Biologics More Related Topics. When given by intravenous infusion it is used once per month after initial doses at baseline, 2 weeks, and 4 weeks.