We know these braces are uncomfortable, but unfortunately they need to be worn when out of bed. Basically wherever you go, the brace must follow you there. The only time the brace may be removed during the day is to clean and dry your incision site. This is necessary to decrease the risk of infection. You may exercise, but start slow and gradually increase your activity. During your first week post-operatively, do not sit for more than 10 minutes at a time. Sitting puts more pressure on your back than does standing or walking. After your first office visit, you may increase your sitting time.
NSAIDs have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects. Although different NSAIDs have different structures, they all work by blocking cyclooxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation. Most NSAIDs inhibit both enzymes, although a few are available that mainly inhibit COX-2. The pain-relieving and anti-inflammatory effects of NSAIDs are mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.