Turning to FIG. 1, there is shown a medicinal aerosol device 10 comprising a pressurizable metal aerosol container 16 equipped with a metering valve 18. The metal container 16 is preferably made of aluminum (. aluminum or aluminum alloy) and has an inert interior coating layer 14. The metering valve 18 includes a metal metering chamber 20 with a coating layer 22. Moreover, although not shown, it is preferred that as many other metal surfaces in contact with the formulation 12 as feasible are also coated with an inert layer (., the interior of the metering chamber). It is also preferred to use a valve design that minimizes metal surfaces in contact with the formulation 12. For example, it is preferred in the context of the present invention to use a plastic valve stem 24 instead of metal.
The fetal adrenal cortex lacks expression of the enzyme early on, thus mineralocorticoids (. aldosterone ) and glucocorticoids (. cortisol ) cannot be synthesized. This is significant because cortisol induces type II pneumocytes of the lungs to synthesize and secrete pulmonary surfactant ; without pulmonary surfactant to reduce the alveolar surface tension , premature neonates may die of neonatal respiratory distress syndrome . If delivery is unavoidable (. because of placental abruption , or pre-eclampsia / HELLP syndrome ), then glucocorticoids (. cortisol) can be administered.